• Card 11 / 24: What is the mechanism of action of Fipronil (Frontline)?
    A) Fipronil inhibits the oxidation of NADH to NAD+ which leads to an energy deficiency in cells.
    B) Fipronil binds to the membrane lipid phase near the Na+ channel.
    C) Fipronil inhibits Na+ influx and K efflux
    D) Fipronil noncompetitively binds GABA receptors and blocks Cl- influx
    E) Fipronil is an AchE inhibitor

    Answer:
    D) Fipronil noncompetitively binds GABA receptors and blocks Cl- influx

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Explanation:

Poison occurs in dogs an cats due to ingestion/licking of Frontline product. Clincal signs are tremors, convulsions and death. Frontline cannot be used on rabbits.

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Pesticides/Small animal poison Test

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